(31-Jul-2019) Publication in Frontiers in Genetics!

Our opinioin paper on the pleiotropic effects of CCR5Δ32 is published in Frontiers in Genetics. We investigated the potential side effects due to genetic pleiotropy of He Jiankui’s CRISPR editing target. The 32bp deletion, though protective against HIV-1 infection, simultaneously carries substantial harmful effects across various human complex diseases. We approached this by looking into GWAS summary statistics in the UK Biobank and mixture modeling of the genetic effects. See also press release by The Intellectural & Sina.

All judgements are, in their rationale, statistics.

-- C. R. Rao

Copyright © 2018-2020 Xia Shen PhD. All rights reserved.